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VCD calculations

As chirality is an extremely important intrinsic property of active pharmaceutical ingredients in view of their activity and possible adverse effects, Silicos offers the ability to get a clear insight in this aspect of the structure-activity relation through the vibrational circular dichroism (VCD) technique.
Besides having some major advantages over other techniques, especially in the domain of sample preparation which is an issue when applying monocrystal X-ray crystallography techniques, VCD can not only determine the absolute configuration of molecules, but can also provide some insight in the conformation of chiral molecules in solution.